Hybrid Biomaterials for Orthopedic and Craniofacial Applications

用于骨科和颅面应用的混合生物材料

• 批准号: RGPIN-2017-04983
• 负责人: Rizkalla, Amin
• 金额: $ 1.75万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=663429
• 关键词: Hybrid; Biomaterials; Orthopedic; Craniofacial; Applications

The rise in life expectancy in developed countries has led to an increase in age-related skeletal diseases such as osteoarthritis, osteoporosis and periodontitis with corresponding increase in demand for materials that can replace and integrate with bone. In addition, over 2.2 million patients per year worldwide undergo surgery for skeletal trauma or tumor resection. The gold standard for bone repair is the autograft. However, limited tissue availability and donor-site morbidity has led to the use of artificial materials. Despite intensive research efforts in the fields of ceramics, metals and polymers, the ideal material is still far from clinical practice. Over the next 5 years, the proposed research program will focus on developing: 1) hybrid scaffolds and vehicles for the controlled release of bioactive and antibacterial molecules; 2) bioactive and antimicrobial hybrid coatings on functionalized 3-D-printed titanium alloys to enhance the interfacial bond with bone; and 3) novel, fast setting and injectable bone cements, which are bioactive and biodegradable. The proposed work will improve our fundamental understanding of and lead to technological breakthroughs in covalently bonded class II hybrid biomaterials for scaffolds, implant coatings, and cements for use in orthopedic, craniofacial and periodontal applications. In addition, I will train well-rounded graduate and undergraduate students in the field of bone tissue engineering and regenerative medicine. The overall program will provide training for three PhD, two Masters and six undergraduate students, exposing them to cutting edge research and development in the synthesis and characterization of hybrid biomaterials. Upon graduation, these students will take leadership roles in bringing biotechnology and medical devices from the laboratory to the marketplace and clinic.**

发达国家预期寿命的提高导致骨关节炎、骨质疏松症和牙周炎等与年龄相关的骨骼疾病增加，对可替代骨并与骨融合的材料的需求也相应增加。此外，全球每年有超过 220 万名患者接受骨骼创伤或肿瘤切除手术。骨修复的黄金标准是自体移植。然而，有限的组织可用性和供体部位发病率导致了人造材料的使用。尽管在陶瓷、金属和聚合物领域进行了大量的研究工作，但理想的材料距离临床实践仍然很远。未来5年，拟议的研究计划将重点开发：1）用于控制释放生物活性和抗菌分子的混合支架和载体； 2）功能化3D打印钛合金上的生物活性和抗菌混合涂层，以增强与骨的界面结合； 3）新颖、快速凝固、可注射的骨水泥，具有生物活性和可生物降解性。拟议的工作将提高我们对用于骨科、颅面和牙周应用的支架、植入物涂层和水泥的共价键合 II 类混合生物材料的基本理解并带来技术突破。此外，我还将培养骨组织工程和再生医学领域全面发展的研究生和本科生。整个项目将为三名博士生、两名硕士生和六名本科生提供培训，让他们接触混合生物材料合成和表征的前沿研究和开发。毕业后，这些学生将在将生物技术和医疗设备从实验室推向市场和诊所方面发挥领导作用。**