Understanding and exploiting ligand-driven nanoparticle interfacial phenomena

理解和利用配体驱动的纳米颗粒界面现象

• 批准号: RGPIN-2018-06594
• 负责人: Meli, Vicki
• 金额: $ 1.75万
• 依托单位: Mount Allison University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=659519
• 关键词: Understanding; exploiting; ligand; driven; nanoparticle

How nanoparticles (NPs) interact with their environment is a question that lies at the heart of many of our most promising potential nanotechnologies: from designing and predicting safe and effective use of NPs within living systems, to forming stretchable or self-healing films and composites, to assembling nanoparticles into superstructures for next generation solar cells, LEDs, and other applications. Nanoparticles present a complex interface through which they can interact with their environment, and this complexity arises from variety of possible NP core shapes and sizes which in turn define the available surface chemistry and the physical properties of the nanoparticle coating. Within the great variety of synthetically-available nanoparticle systems, thiol-capped gold nanoparticles are among the most thoroughly studied. Despite this fact, there remain many fundamental questions regarding how NPs behave in different environmental conditions (i.e. what makes a “good solvent” good? How can this influence how NPs interact with biological membranes?). Such questions are central to the counter-intuitive trends often observed in the physical properties (solubility and self-assembly) previously observed in these systems.***This research program will improve our understanding of the physical properties (mixing) of a model nanoparticle system consisting of spherical thiol-capped gold nanoparticles of various gold core sizes and thiol capping layer densities. We aim to achieve insights that can be applied to nanoparticles in general, and subsequently will be used to study more complex nanoparticle systems consisting of mixed capping layers consisting of two types of ligands (hydrophobic/philic) as well rod-shaped nanoparticles. By controlling interfacial parameters (temperature, solvation affinity to the oil or water phase), we will clarify some of the key nanoparticle properties in different environments and establish much needed guidelines for designing nanoparticles for a given application.

纳米颗粒 (NP) 如何与其环境相互作用是我们许多最有前途的潜在纳米技术的核心问题：从设计和预测纳米颗粒在生命系统中安全有效的使用，到形成可拉伸或自修复的薄膜和复合材料，将纳米粒子组装成下一代太阳能电池、LED 和其他应用的上层结构，纳米粒子呈现出一个复杂的界面，通过该界面它们可以与环境相互作用，而这种复杂性源于各种可能性。纳米粒子核的形状和尺寸反过来又决定了纳米粒子涂层的可用表面化学和物理性质，尽管如此，在各种可用的合成纳米粒子系统中，硫醇封端的金纳米粒子是研究最深入的。关于纳米粒子在不同环境条件下如何表现，仍然存在许多基本问题（即什么才是“好溶剂”？这如何影响纳米粒子与生物膜的相互作用？）。先前在这些系统中观察到的物理性质（溶解度和自组装）中经常观察到反直觉的趋势。***该研究计划将提高我们对由球形硫醇组成的模型纳米粒子系统的物理性质（混合）的理解我们的目标是获得可应用于一般纳米粒子的见解，并随后用于研究由混合组成的更复杂的纳米粒子系统。由两种类型的配体（疏水/亲水）以及棒状纳米颗粒组成的覆盖层通过控制界面参数（温度、对油相或水相的溶剂化亲和力），我们将阐明不同环境和条件下的一些关键纳米颗粒特性。为给定应用设计纳米粒子建立急需的指南。