X-ray scatter imaging: Cross sections, collimation, speed, and signal extraction

X 射线散射成像：横截面、准直、速度和信号提取

• 批准号: 42307-2013
• 负责人: Johns, Paul
• 金额: $ 1.53万
• 依托单位: Carleton University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=654714
• 关键词: ray; scatter; imaging; Cross; sections

Despite the advances in mri, nuclear medicine, and ultrasound, x-ray imaging remains the main tool used in medicine to look inside the body. Physics innovations now suggest new ways of using x rays to capture more information.** All medical x-ray imaging today uses the "primary" or transmitted x rays to form a "shadow" picture of the patient. Scattered x rays, however, comprise up to 90% of the radiation at the image receptor and are another information source. Our lab's focus is to develop an x-ray imaging system that uses scatter as well as primary.** We will: (1) Complete building a library of diffraction signals of tissues, notably brain grey and white matter, and tracers for bone metabolism, using instrumentation developed at Carleton University. (2) Continue our work at the Canadian Light Source (CLS) synchrotron in Saskatoon to design geometries of the radiation beam (collimation) for x-ray scatter imaging. We are using the BioMedical Imaging & Therapy beamline at CLS, whose monoenergetic beam and radiation instrumentation provide an ideal environment for machine development. We seek the best tradeoff between scanning a single narrow beam in tandem with a pixelated scatter detector over the patient, which will be prohibitively slow but will capture all scatter information unambiguously, versus multibeam geometries in which the scatter patterns overlap, which will speed acquisition but require untangling algorithms to use. So far, we have demonstrated 5-beam imaging with a digital detector and successful disentanglement. (3) We will commence biomedical applications, starting with imaging tracers for bone metabolism, and prostate imaging. (4) We will transfer the concept to standard x-ray systems such as in hospitals.** These innovations in x-ray imaging are commercializable and applicable beyond medicine to industrial nondestructive testing, to security imaging, and to all other areas in which x rays are shone through an object. We will seek further funding to help commercialize once the basic approach has been established.****************************

尽管MRI，核医学和超声检查取得了进步，但X射线成像仍然是医学中用于观察体内的主要工具。 现在，物理创新提出了使用X射线捕获更多信息的新方法。 然而，散射的X射线最多占图像受体的辐射的90％，是另一个信息来源。 我们的实验室的重点是开发一个X射线成像系统，该系统使用散射以及主要的。 （2）继续在萨斯卡通的加拿大光源（CLS）同步加速器上继续我们的工作，以设计X射线散射成像的辐射光束（准确）的几何形状。 我们正在使用CLS的生物医学成像和治疗束线，其单必须光束和辐射仪为机器开发提供了理想的环境。 我们寻求最好的折衷方案，与患者的像素化散射探测器一起扫描单个狭窄的光束，这将非常缓慢，但会明确地捕获所有散点信息，而散点模式重叠的多层几何形状，这将加速摄取，但需要加快算术的算法。 到目前为止，我们已经通过数字探测器和成功的脱离了5梁成像。 （3）我们将开始生物医学应用，从成像骨骼代谢和前列腺成像开始。 （4）我们将把概念转移到标准的X射线系统中，例如在医院中。 一旦建立了基本方法，我们将寻求进一步的资金来帮助商业化。******************************************