Defining mechanisms of PI4P-dependent transport during secretory granule biogenesis

分泌颗粒生物发生过程中 PI4P 依赖性运输的定义机制

• 批准号: 390823
• 负责人: Brill Julie A
• 金额: $ 66.6万
• 依托单位: Hospital for Sick Children (Toronto)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-09-01 至 2023-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=390823&lang=en
• 关键词: Drosophila; Endosomes; Fluorescence Microscopy; Lipid Transfer; Membrane Contact Sites; Membrane Trafficking; Molecular Genetics; Phosphatidylinositol Phosphates; Pi 4-Kinases; Secretory Granule Biogenesis

Each of our cells is like a busy city, with fleets of trucks that pick up and deliver cargo to specific destinations. Instead of street signs, the drivers of these vehicles find the correct address by reading signals provided by lipids, which are fatty mo

我们的每个单元就像一座繁忙的城市，拥有卡车车队，负责将货物运送到特定目的地。这些车辆的驾驶员不是通过路牌找到正确的地址，而是通过读取脂质提供的信号来找到正确的地址，脂质是脂肪分子。