Cryopreservation of livestock colostrum-derived mesenchymal stem cells

家畜初乳来源的间充质干细胞的冷冻保存

• 批准号: 521869-2017
• 负责人: Elliott, Janet
• 金额: $ 1.82万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=640560
• 关键词: Cryopreservation; livestock; colostrum; derived; mesenchymal

Currently, antibiotics are widely used to prevent and control disease and infections in farm animals such as pigsand cows. However, the continued use of antibiotics in animals meant for human consumption can cause thegrowth of bacteria that become resistant to antibiotics. These harmful bacteria can also be passed on to humansvia the food chain. Health Canada is moving to phase out the use of some antibiotics in the animal industry tolimit the danger posed to the public by antibiotic-resistant bacteria in meat and other animal products.Therefore, new, safe and efficient strategies are needed to improve overall immunity and general health oflivestock by preventing disease/infection without the use of antibiotics. MySteM Biotechnologies Inc.(MySteMBiotech) is developing a new product composed of cells from the milk of pigs and cows that can beused instead of antibiotics. The source of the cells is the colostrum, the "first milk" released during the fewdays within the time the animals give birth. While it is widely known that colostrum is rich in antibodies, theirpreliminary results show that it also contains a special type of cells called mesenchymal stem cells (MSCs).These cells have the ability to boost the body's protective response against microorganisms that can causedisease. The company has successfully isolated these cells from pig and cow colostrum and grown them inculture to increase their numbers. They have also shown that these cells have the ability to wipe out bacteria inculture. Our expertise in the field of long-term storage of live cells and tissues will address the company's needfor strategies to freeze the cells so they can be kept alive for future use and in a form that can be readily andsafely given to farm animals. The enabling and innovative technology that is anticipated to result from thisstudy represents a natural and economic approach to enhance the health of Canada's livestock and boost ouragriculture and agri-food industry.

目前，抗生素被广泛用于预防和控制猪牛等农场动物的疾病和感染。但是，在用于人类食用的动物中，继续使用抗生素会导致细菌的生长，这些细菌对抗生素具有抗药性。这些有害细菌也可以传递给食物链人类。加拿大卫生部正在逐步逐步淘汰一些抗生素在肉类和其他动物产品中抗生素耐药细菌对公众构成的危险。因此，需要采取新的，安全有效的策略来改善整体免疫力和通过无需使用抗生素的疾病/感染而进行的整体免疫力和普通健康。 Mystem Biotechnologies Inc.（MyStemBiotech）正在开发一种新产品，该产品是由猪和牛牛奶中的细胞组成的，这些细胞可以用来归为抗生素。细胞的来源是初乳，这是动物分娩后几天内释放的“第一牛奶”。尽管众所周知，初乳富含抗体，但其主要结果表明，它还包含一种特殊的细胞，称为间充质干细胞（MSC）。这些细胞具有增强人体对微生物的保护性反应的能力。该公司已成功地将这些细胞从猪和牛初乳中分离出来，并将它们种植起来以增加其数量。他们还表明，这些细胞具有消除细菌培养的能力。我们在长期存储活细胞和组织领域的专业知识将满足公司冻结细胞的策略的需求，以便可以将它们存活以供将来使用，并且可以很容易地且可以赋予农场动物。预计由本研究所产生的有利和创新技术代表了一种自然而经济的方法，可以增强加拿大牲畜健康，并增强我们的我们的农业和农业食品行业。