Development of vascular phantoms for ablation catheter technology optimization

开发血管模型以优化消融导管技术

• 批准号: 508687-2017
• 负责人: Mongrain, Rosaire
• 金额: $ 1.82万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=639460
• 关键词: Development; vascular; phantoms; ablation; catheter

Cardiovascular diseases affect 36.9% of the population. It is estimated that 4-5 million people are affected byatrial fibrillation (irregular heart beat) in the US and about 350000 in Canada. An important treatment iscatheter ablation of the erratic conductive cells causing the fibrillation, located near the pulmonary veins ostiain the left atrium. Catheter ablation involves the insertion of a catheter in the groin and directed via the venacava into the right atria. The septal wall between the right atrium and the left atrium is punctured to access thepulmonary veins ostia. The catheter tip delivers energy (radio frequency, cryogenic, ultrasound) to isolate theerratic conductive cells. However, catheter ablation is associated with complications rates of about 4.5%including atrio-esophageal fistula, a life threatening condition. Improvement of the technology requires aprecise assessment of the orientation, positioning, contact forces and navigation through the tissue and deliveryof the energy for achieving the desired isolation while avoiding unwanted perforation and burn/freeze. AgileMV is developing an adjunctive device to ablation catheters that has the potential to provide better positioning,reduce associated potential vessel damage while decreasing the intervention time for an improved patientoutcome and lower hospital/physician costs. In this project, we propose to use a methodology that wedeveloped for making anatomically and biomechanically correct hydrogel vascular phantoms to reproduce thespecific anatomy of the left atrium, right atrium and vena cava to optimize the biomechanical parameters ofAgile MV's design to ensure most favorable treatment. We will use an approach that we developed for othervascular structures (ascending aorta, AAA) and customize it for Agile's project by reconstructing the vena cava,right atrium and left atrium. This approach makes uses of PVA (PolyVinyl Alcohol) to reproduce the elasticproperties of vascular tissue. This provides realistic and reproducible vascular phantoms for testinginterventional technology.

心血管疾病影响36.9％的人口。据估计，在美国，有4-500万人受到影响的拜拜颤振（心跳不规则），加拿大约有350000人。不稳定的导电细胞的一项重要治疗仪消融，导致纤颤，位于左心房的肺静脉附近。导管消融涉及将导管插入腹股沟，并通过Venacava引导到右心房。右心房和左心房之间的间隔壁被刺穿以进入肺静脉。导管尖端提供能量（射频，低温，超声）以分离导电细胞。但是，导管消融与大约4.5％的并发症发生率有关，包括心脏食道瘘，这是一种威胁生命的疾病。技术的改进需要对方向，定位，接触力和通过组织的定位，定位，接触力和导航的能量进行评估，以实现所需的隔离，同时避免不必要的穿孔和燃烧/冻结。 AgileMV正在为消融导管开发一种辅助装置，该设备有可能提供更好的定位，减少相关的潜在血管损害，同时减少改善患者的干预时间和较低的医院/医师费用。在这个项目中，我们建议使用一种方法来进行解剖和生物力学上正确的水凝胶血管幻像，以重现左心房，右心房和静脉腔的台化解剖结构，以优化Agagile MV设计的生物力学参数，以确保最佳的治疗。我们将使用我们为其他血管结构（上升主动脉，AAA）开发的方法，并通过重建腔静脉，右心房并左心房来定制敏捷项目。这种方法利用PVA（聚乙烯基醇）重现血管组织的弹性。这为测试干预技术提供了现实且可重现的血管幻象。