Comprehensive Experimental and Numerical Studies of Pharmaceutical Aerosol Devices

药用气雾剂装置的综合实验和数值研究

• 批准号: RGPIN-2016-06239
• 负责人: Matida, Edgar
• 金额: $ 1.89万
• 依托单位: Carleton University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=638459
• 关键词: Comprehensive; Experimental; Numerical; Studies; Pharmaceutical

Pressurized metered-dose inhalers (pMDIs) or “puffers”, dry powder inhalers (DPIs), and nebulizers are normally used in the treatment of lung diseases, such as asthma and bronchitis. Statistics from Lung Associations indicate that up to approximately 10% of the population may suffer from respiratory illnesses requiring treatment in part of their lives. Inhaler devices produce very complex turbulent flows and ideal medication delivery remains a challenging engineering problem. Considerable amounts of aerosol medication generated from the pMDIs are deposited and lost on the walls of the upper airways (mouth-throat-trachea) before reaching the target (or the lungs), resulting in considerable medication losses from a single dosage (Fink, 2000). Add-on spacers (normally cylindrical chambers) are devices that are attached to the pMDIs and will enhance the total amount of medication delivered to the lungs.

加压计量吸入器 (pMDI) 或“吹气器”、干粉吸入器 (DPI) 和雾化器通常用于治疗肺部疾病，例如哮喘和支气管炎。肺脏协会的统计数据表明，高达约 10% 的患者会使用这种吸入器。人们在生活中可能会患有呼吸系统疾病，需要接受治疗。吸入器会产生非常复杂的湍流，而理想的药物输送仍然是一个具有挑战性的工程问题。 PMDI 产生的气溶胶药物在到达目标（或肺部）之前会沉积并损失在上呼吸道（口-咽-气管）壁上，导致单剂量药物损失相当大（Fink，2000）。隔离器（通常为圆柱形腔室）是连接到 pMDI 的装置，可增加输送到肺部的药物总量。