Non-mechanical continuous flow micropumps for biomedical applications

用于生物医学应用的非机械连续流微型泵

• 批准号: 386864-2012
• 负责人: Dalton, Colin
• 金额: $ 1.53万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=637100
• 关键词: Non; mechanical; continuous; flow; micropumps

This research will focus on investigating non-mechanical micropumping methods for making small devices to pump fluid in bio-medical devices. The fluid will be pumped using electricity through small microneedles. The chosen area of research is specifically aimed at improving patient care by removing the need for hypodermic syringes and providing the path into automated drug delivery methods. Specifically, AC electrokinetic techniques will be investigated for pumping fluids through custom made silicon microneedle arrays. Microneedle arrays penetrate the upper part of skin, avoiding the nerves, allowing for practically painless skin penetration. The investigation will focus on the need to create small, low power, reliable devices. Traditional methods of fabricating the devices will be used initially, such as photolithography, coupled with computer simulations to design optimal devices. During the later stages of the research, fabrication will transition to alternate technologies, such as commercial silicon chip manufacturing processes and laser micromachining. To achieve these goals, a series of experimental testing, simulation and design optimization of AC electrokinetic micropumps will be conducted. The experimental data will be compared with simulation data and the simulation models modified accordingly, iteratively leading to new designs of micropumps. The research methodology will involve investigating several electrokinetic micropumping factors, such as voltages and currents applied; temperature issues such as damage to the fluid solution, fluid properties within microfluidic channels and also the geometry of the electrode arrays and the microfludics channels themselves. These devices will form an integral part of a biomedical engineering solution for healthcare.

这项研究将着重于研究非机械微型倾斜方法，以制造小型设备在生物医学设备中泵送流体。流体将通过小微针使用电力泵送。选择的研究领域专门旨在通过消除皮下注射注射器的需求并提供自动药物输送方法来改善患者护理。具体而言，将研究AC电动技术通过定制的硅微针阵列泵送流体。微针阵列穿透皮肤的上部，避免神经，从而使皮肤无痛。调查将集中于创建小型，低功率，可靠设备的需求。制造设备的传统方法最初将使用，例如光刻学，再加上计算机模拟来设计最佳设备。在研究的后期阶段，制造将过渡到替代技术，例如商业硅芯片制造工艺和激光微加工。为了实现这些目标，将进行一系列实验测试，模拟和设计优化，对AC电动微型聚集体进行。实验数据将与仿真数据进行比较，并相应地修改了模拟模型，从而导致了新的微型泵设计。研究方法将涉及研究几种电动微倾斜因子，例如使用的电压和电流。温度问题，例如对流体溶液的损坏，微流体通道内的流体特性，以及电极阵列的几何形状和微塑料通道本身。这些设备将成为医疗保健生物医学工程解决方案的组成部分。