Antifouling biosensor technology for bioanalytical detection in precision medicine

用于精准医学生物分析检测的防污生物传感器技术

• 批准号: RGPIN-2017-05916
• 负责人: Thompson, Michael
• 金额: $ 1.38万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=632596
• 关键词: Antifouling; biosensor; technology; bioanalytical; detection

Precision medicine is a relatively new activity in the field that concentrates on the disease experienced by a particular patient. Conditions vary from patient to patient because of genetic and environmental factors. A key component of this area of medicine is the assay of progression of a specific disease including the possibility for early detection. This involves the quantitative determination of biomarkers for the disease as they appear ion blood, urine and tissue samples. Biomarkers are species , for example, that are released by tumors that signal the presence of particular disease such as cancer, whether of a genetic of infectious type. This proposal describes research towards the assay of such moieties in human serum using biosensor technology. The latter involves the binding of the target biomarker at the surface of an electronic transducer. In the proposed work, such a device will be based on ultra-high frequency acoustic physics. A special component of this type of detection is the capability for operation in fluids such serum where large scale interference from proteins is anticipated. This proposal includes a strategy to prevent this deleterious effect.

精准医学是该领域相对较新的活动，专注于特定患者所经历的疾病。由于遗传和环境因素，每个患者的病情都有所不同。 该医学领域的一个关键组成部分是对特定疾病进展的分析，包括早期检测的可能性。这涉及到血液、尿液和组织样本中出现的疾病生物标志物的定量测定。例如，生物标志物是由肿瘤释放的物种，它们发出信号表明特定疾病（例如癌症）的存在，无论是遗传性还是传染性类型。 该提案描述了使用生物传感器技术测定人血清中此类部分的研究。后者涉及目标生物标志物在电子传感器表面的结合。 在拟议的工作中，这种设备将基于超高频声学物理学。此类检测的一个特殊组成部分是能够在血清等液体中进行操作，预计会受到蛋白质的大规模干扰。该提案包括防止这种有害影响的策略。