Epigenetic regulation of repeat expression by RB and EZH2 in cancer

癌症中 RB 和 EZH2 重复表达的表观遗传调控

• 批准号: 370044
• 负责人: Dick Frederick A
• 金额: $ 63.53万
• 依托单位: London Health Sciences Centre Res. Inc. (Ont.)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-09-01 至 2022-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=370044&lang=en
• 关键词: Cancer; Endogenous Retrovirus; Heterochromatin; Histone Methyl Transferase; Line Element; Mutation; Retinoblastoma; Retrotransposition; Transgenic Mouse; Cancer; Endogenous Retrovirus; Heterochromatin; Histone Methyl Transferase; Line Element; Mutation; Retinoblastoma; Retrotransposition; Transgenic Mouse

Cancer cells possess a number of features that distinguish them from the normal cells in our bodies. This grant application is focused on studying the remnants of ancient infections that leave behind foreign DNA sequences called repeats. Their expression

癌细胞具有许多特征，可以将它们与我们体内的正常细胞区分开。该赠款应用的重点是研究古代感染的残留物，这些遗迹留下了称为重复序列的外来DNA序列。他们的表达