Chromosome organization by RB and Condensin II in metastasis.

转移中由 RB 和凝缩蛋白 II 形成的染色体。

• 批准号: 418627
• 负责人: Dick Frederick A
• 金额: $ 68.83万
• 依托单位: London Health Sciences Centre Res. Inc. (Ont.)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-03-01 至 2025-03-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=418627&lang=en
• 关键词: Chemotherapy; Condensin; Drug Resistance; Genome Instability; Metastasis; Retinoblastoma; Sarcoma; Chemotherapy; Condensin; Drug Resistance; Genome Instability; Metastasis; Retinoblastoma; Sarcoma

This proposal is focused on how cancer cells gain more aggressive characteristics and progress to metastatic disease. We have uncovered a molecular mechanism controlled by a gene called RB1 that is disproportionately altered in metastatic cancer compared

该提案的重点是癌细胞如何获得更具侵略性的特征并发展为转移性疾病。我们发现了一种由称为RB1的基因控制的分子机制，该基因在转移性癌症中的变化不成比例。