Coxsackie and adenovirus receptor (CAR): a multifunctional cell adhesion molecule

柯萨奇和腺病毒受体（CAR）：多功能细胞粘附分子

• 批准号: RGPIN-2017-05782
• 负责人: Nalbantoglu, Josephine
• 金额: $ 2.04万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629409
• 关键词: Coxsackie; adenovirus; receptor; CAR; multifunctional

The Coxsackie and adenovirus receptor (CAR) is a member of the immunoglobulin superfamily of adhesion molecules. As its name implies, it was first identified as the high affinity receptor for adenovirus type 5, the most commonly used adenoviral vector for gene transfer. My laboratory's interest in CAR stems from the fact that we routinely use adenovirus (Ad) vectors for gene transfer to muscle, nervous system and tumour cells. As such we have been interested in determining the expression pattern of CAR and means of modulating its expression. In the process, we have started studying the multiple functions of CAR in these tissues.

柯萨奇腺病毒受体 (CAR) 是粘附分子免疫球蛋白超家族的成员。顾名思义，它首先被鉴定为 5 型腺病毒的高亲和力受体，5 型腺病毒是最常用的基因转移腺病毒载体。我的实验室对 CAR 的兴趣源于这样一个事实：我们经常使用腺病毒 (Ad) 载体将基因转移到肌肉、神经系统和肿瘤细胞。因此，我们一直对确定 CAR 的表达模式以及调节其表达的方法感兴趣。在此过程中，我们开始研究 CAR 在这些组织中的多种功能。