A CBT-Based Text Messaging Intervention for Methamphetamine Dependence

基于 CBT 的甲基苯丙胺依赖短信干预

基本信息

批准号：
9261629
负责人：
GANTT P GALLOWAY
金额：
$ 8.16万
依托单位：
FRIENDS RESEARCH INSTITUTE, INC.
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-04-15 至 2017-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9261629
关键词：
CBT Based Text Messaging Intervention

项目摘要

DESCRIPTION (provided by applicant): This application proposes to improve treatment outcomes for methamphetamine- (MA-) dependent subjects through development of an innovative cognitive behavioral therapy- (CBT-) based text messaging intervention. While CBT reduces MA use, it and other psychosocial therapies have limited effectiveness, and patients treated for MA dependence have a high rate of relapse. Thus, a significant need exists for add-on therapy for treatment of MA dependence. We are using an iterative process to develop and refine this intervention. We have convened an expert panel, conducted three focus groups with MA-dependent subjects, interviewed 25 subjects being treated for MA dependence, and conducted a five-subject feasibility trial. We will reconvene the expert panel to review our candidate text messages and study methods. Active and control text messages will be uploaded into a web-based application that we have developed for this purpose. We will conduct a pre-test in which 10 subjects receive two weeks of the active text messages and two weeks of control text messages; these conditions will be in random, counterbalanced order with a one-week washout. Messages will be "pushed" to subjects four times per day and can also be "pulled" on an as-requested basis. Subjects will attend one-hour CBT-based group therapy sessions three times per week. We will collect urine samples for toxicological analyses, self-reports of MA use, craving scores, and ratings of the utility and acceptability of the intervention Qualitative interviews after subjects complete each condition will assess the perceived utility of the approach, preferences for message content, and acceptability. When all subjects have completed, we will hold a focus group and reconvene the expert panel. After making any indicated revisions to the text messages or procedures, we will implement a second crossover trial with 40 subjects, conduct another focus group with subjects who were in the second trial, reconvene the expert panel again, and select text messages to be used in a subsequent large randomized parallel group trial. This will be an inexpensive intervention to deploy that utilizes technology that is affordable and widely available - basic cellular telephones. The low-intensity, high-frequency, and always available characteristics of this intervention contrast to conventional outpatient treatment and may be a valuable complement to it. It will be readily extensible, both to MA users who cannot attend formal treatment, and also to individuals dependent on other drugs.

描述（由申请人提供）：本申请提出通过开发基于创新的认知行为疗法（CBT）的短信干预来改善甲基苯丙胺（MA）依赖性受试者的治疗结果。虽然 CBT 减少了 MA 的使用，但它和其他心理社会疗法的效果有限，并且接受 MA 依赖治疗的患者复发率很高。因此，非常需要用于治疗MA依赖性的附加疗法。我们正在使用迭代过程来开发和完善这种干预措施。我们召集了一个专家小组，对 MA 依赖受试者进行了三个焦点小组，采访了 25 名正在接受 MA 依赖治疗的受试者，并进行了一项 5 受试者的可行性试验。我们将重新召集专家小组来审查我们的候选人短信和研究方法。主动和控制文本消息将上传到我们为此目的开发的基于网络的应用程序中。我们将进行预测试，其中 10 名受试者接收两周的活动短信和两周的控制短信；这些条件将以随机、平衡的顺序排列，并以一周为周期进行淘汰。消息每天将被“推送”四次给主题，也可以根据请求“拉取”。受试者每周将参加 3 次每次一小时的基于 CBT 的团体治疗课程。我们将收集尿液样本进行毒理学分析、MA 使用的自我报告、渴望评分以及干预的效用和可接受性评级。受试者完成每种条件后的定性访谈将评估该方法的感知效用、对信息内容的偏好、和可接受性。当所有科目完成后，我们将召开焦点小组会议并重新召集专家小组。在对短信或程序进行任何指示的修改后，我们将与 40 名受试者进行第二次交叉试验，与第二次试验中的受试者进行另一个焦点小组，再次重新召集专家小组，并选择要在随后进行的大型随机平行组试验。这将是一种廉价的干预措施，其部署利用的是负担得起且广泛使用的技术——基本蜂窝电话。这种干预措施具有低强度、高频率和随时可用的特点，与传统的门诊治疗形成鲜明对比，可能是对其的宝贵补充。它可以很容易地扩展到无法参加正规治疗的 MA 使用者，以及依赖其他药物的个人。