METHAMPHETAMINE DEPENDENCE AND THE RISK OF HIV INFECTION

甲基苯丙胺依赖和艾滋病毒感染风险

• 批准号: 6378651
• 负责人: GANTT P GALLOWAY
• 金额: $ 32.8万
• 依托单位: HEALTHRIGHT 360
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6378651
• 关键词: HIV infections; behavior prediction; behavioral /social science research tag; clinical research; comorbidity; drug addiction; hepatitis B; hepatitis C; high risk behavior /lifestyle; human T cell leukemia; human subject; methamphetamine; psychological tests; sex behavior; substance abuse epidemiology; substance abuse related behavior

DESCRIPTION: (Applicant's Abstract) Methamphetamine (MA) dependence is expanding rapidly in the United States, recapitulating early phases of epidemic spread in the 1950's and 1960's. Beyond the morbidity and mortality directly associated with addictive disease, MA is of particular concern in light of the HIV epidemic because it is often administered intravenously and it often increases libido. This confluence of sexual and injection drug use (IDU) risk factors has led to high HIV seroprevalence in MA using populations. Despite the rapid increase in MA dependence, little is known of its natural history and the relative contributions of sexual and IDU behaviors to the risk of HIV transmission. In a longitudinal study of MA dependence, we will use a comprehensive battery of assessments to identify predictors of high risk behaviors; the relative contributions of various sexual and IDU factors to HIV seropositivity; rates of HIV seroconversion; changes in risk behaviors and MA use following drug treatment; and the prevalence and stability of psychiatric comorbidity. Subjects will be recruited from the largely homosexual outpatient population at Haight Ashbury Detox in San Francisco, from predominately heterosexual outpatient population at The Effort in Sacramento, and from out-of-treatment MA users in San Francisco and Sacramento.

描述：（申请人摘要） 在美国，甲基苯丙胺 (MA) 依赖正在迅速扩大， 回顾 1950 年代和 1960 年代流行病传播的早期阶段。 除了与成瘾直接相关的发病率和死亡率之外 鉴于艾滋病毒的流行，MA 受到特别关注，因为它 通常静脉注射，并且通常会增加性欲。 这 性行为和注射吸毒 (IDU) 危险因素的结合导致 MA 使用人群中 HIV 血清阳性率较高。 尽管对 MA 的依赖性迅速增加，但人们对它的天然作用却知之甚少。 性行为和注射吸毒者行为的历史以及对 艾滋病毒传播的风险。 在 MA 依赖性的纵向研究中，我们将 使用全面的评估来确定高风险的预测因素 危险行为；各种性因素和注射吸毒者因素的相对贡献 HIV 血清阳性； HIV 血清转化率；风险的变化 药物治疗后的行为和 MA 使用；以及患病率和 精神共病的稳定性。 受试者将从 旧金山海特阿什伯里戒毒所的门诊病人主要是同性恋 Francisco，来自以异性恋为主的门诊患者群体 萨克拉门托以及旧金山未接受治疗的 MA 用户的努力 和萨克拉门托。

项目成果

Attentional control and brain metabolite levels in methamphetamine abusers.

甲基苯丙胺滥用者的注意力控制和大脑代谢物水平。

• 发表时间: 2007-06-01
• 影响因子: 10.6
• 作者: Salo, Ruth;Nordahl, Thomas E;Natsuaki, Yutaka;Leamon, Martin H;Galloway, Gantt P;Waters, Christy;Moore, Charles D;Buonocore, Michael H
• 通讯作者: Buonocore, Michael H

Cognitive function and nigrostriatal markers in abstinent methamphetamine abusers.

戒断甲基苯丙胺滥用者的认知功能和黑质纹状体标记。

• 发表时间: 2006-04
• 影响因子: 3.4
• 作者: Johanson, Chris;Frey, Kirk A;Lundahl, Leslie H;Keenan, Pamela;Lockhart, Nancy;Roll, John;Galloway, Gantt P;Koeppe, Robert A;Kilbourn, Michael R;Robbins, Trevor;Schuster, Charles R
• 通讯作者: Schuster, Charles R

Cognitive control and white matter callosal microstructure in methamphetamine-dependent subjects: a diffusion tensor imaging study.

甲基苯丙胺依赖性受试者的认知控制和白质胼胝体微观结构：扩散张量成像研究。

• 发表时间: 2009-01-15
• 影响因子: 10.6
• 作者: Salo, Ruth;Nordahl, Thomas E;Buonocore, Michael H;Natsuaki, Yutaka;Waters, Christy;Moore, Charles D;Galloway, Gantt P;Leamon, Martin H
• 通讯作者: Leamon, Martin H

Hospitalization of patients with cocaine and amphetamine use disorders from a psychiatric emergency service.

患有可卡因和安非他明使用障碍的患者因精神科紧急服务而住院。

• 发表时间: 2002-11
• 作者: Leamon, Martin H;Gibson, David R;Canning, Robert D;Benjamin, Lloyd
• 通讯作者: Benjamin, Lloyd

Methamphetamine users in sustained abstinence: a proton magnetic resonance spectroscopy study.

甲基苯丙胺使用者持续戒断：质子磁共振波谱研究。

• DOI: 10.1001/archpsyc.62.4.444
• 发表时间: 2005-04-01
• 期刊: Archives of general psychiatry
• 作者: T. Nordahl;R. Salo;Yutaka Natsuaki;G. Galloway;Christy Waters;C. Moore;S. Kile;M. Buonocore
• 通讯作者: M. Buonocore