Unconventional ER exit pathway in mammalian Cells

哺乳动物细胞中非常规的 ER 退出途径

• 批准号: RGPIN-2015-04077
• 负责人: Kim, Peter
• 金额: $ 2.77万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629271
• 关键词: Unconventional; ER; exit; pathway; mammalian

A hallmark of eukaryotic cells is the diverse array of subcellular organelles that compartmentalize the various biochemical reactions essential to life. These cells have developed elegant cellular processes to form and maintain the various organelles based on the needs of the cell. One such process is the correct targeting of proteins to their designated organelle to allow for the specialized functions of the organelle. A defect in protein targeting can lead to failure of critical cellular processes leading to cell death and/or disease.

真核细胞的标志是各种各样的亚细胞细胞器，它们使对生命必不可少的各种生化反应划分。这些细胞开发出优雅的细胞过程，以根据细胞的需求形成和维护各种细胞器。这样的过程之一就是将蛋白质正确靶向其指定的细胞器，以允许细胞器的专门功能。蛋白质靶向的缺陷会导致关键细胞过程失败，导致细胞死亡和/或疾病。