Investigating mechanisms of action of silver oxynitrate: an unexplored silver compound with superior anti-biofilm activity.

研究硝酸氧银的作用机制：一种未经开发的银化合物，具有优异的抗生物膜活性。

• 批准号: 501022-2016
• 负责人: Khursigara, Cezar
• 金额: $ 3.9万
• 依托单位: University of Guelph
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Development Grants
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=619109
• 关键词: Investigating; mechanisms; action; silver; oxynitrate

Silver has been used as an antimicrobial compound for thousands of years. Although interest in silver waned in the 1940s with the advent of antibiotic technologies, incidence of antibiotic resistance led to a resurgence in silver antimicrobial technologies in the 1980s. Since then, a variety of silver compounds have been used in topical antimicrobial applications, however, there is still no consensus on the efficacy of silver and mechanistic studies of silver activity are restrictive to singly ionic silver. As a consequence, silver compounds have a tarnished reputation. This project will be the first investigation into mechanisms of action and resistance for a range of silver compounds including the novel silver oxynitrate. Differentiating silver mechanisms of action and antimicrobial resistance will provide a greater understanding of efficacy, establishing structure for consensus, clinical use, and new technological developments. These findings will provide clinicians and patients with effective options for the management of antibiotic resistant infections. Resulting in lessened incidence of infection and associated costs, currently estimated at CAD$ 1 Billion, within the Canadian Health Care System.

数千年来，银一直被用作抗菌化合物。尽管随着 20 世纪 40 年代抗生素技术的出现，人们对白银的兴趣逐渐减弱，但抗生素耐药性的出现导致了 20 世纪 80 年代银抗菌技术的复兴。从那时起，各种银化合物已被用于局部抗菌应用，然而，对于银的功效仍然没有达成共识，并且银活性的机理研究仅限于单离子银。因此，银化合物的声誉受损。该项目将首次研究一系列银化合物（包括新型硝酸银）的作用和耐药机制。区分银的作用机制和抗菌素耐药性将有助于更好地了解功效，建立共识、临床使用和新技术发展的结构。这些发现将为临床医生和患者提供治疗抗生素耐药性感染的有效选择。从而减少了加拿大医疗保健系统内的感染发生率和相关费用，目前估计为 10 亿加元。