Post-transcriptional regulation of gene expression in S. cerevisiae

酿酒酵母基因表达的转录后调控

• 批准号: 435985-2013
• 负责人: Smibert, Craig
• 金额: $ 2.19万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=596827
• 关键词: Post; transcriptional; regulation; gene; expression

The growth and development of all multi-celled organisms, including humans, requires cells within the body to adopt specialized functions. Cell specialization involves the presence of different proteins in different cell types, for example, muscle proteins in muscle cells and liver proteins in liver cells. Cells produce individual proteins by using specific signals known as mRNAs in a process called translation. We are studying two mechanisms that control what proteins are present in cells: translational regulation and mRNA degradation. Translational regulation involves mechanisms can turn on or off the translation of specific mRNAs, thereby controlling the production of the corresponding protein. mRNA degradation blocks the production of a protein by destroying the corresponding mRNA.

所有多细胞生物（包括人类）的生长和发育都需要体内的细胞发挥专门的功能。细胞特化涉及不同细胞类型中存在不同的蛋白质，例如肌肉细胞中的肌肉蛋白和肝细胞中的肝蛋白。细胞通过在称为翻译的过程中使用称为 mRNA 的特定信号来产生单独的蛋白质。我们正在研究两种控制细胞中蛋白质存在的机制：翻译调节和 mRNA 降解。翻译调控涉及可以打开或关闭特定 mRNA 翻译的机制，从而控制相应蛋白质的产生。 mRNA 降解通过破坏相应的 mRNA 来阻止蛋白质的产生。