Conference: 2024 Post-Transcriptional Gene Regulation Gordon Research Conference and Seminar: The Versatility of RNA in the Living World

会议：2024年转录后基因调控戈登研究会议及研讨会：RNA在生活世界中的多功能性

• 批准号: 2422760
• 负责人: Nicholas Conrad
• 金额: $ 2.08万
• 依托单位: Gordon Research Conferences
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2024
• 资助国家: 美国
• 起止时间: 2024-04-15 至 2025-03-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2422760&HistoricalAwards=false
• 关键词: Conference; 2024; Post; Transcriptional; Gene

This award will provide support for the 2024 Gordon Research Conference (GRC) on Post-Transcriptional Gene Regulation titled “The Versatility of RNA in the Living World” as well as its associated Gordon Research Seminar (GRS), “RNA in Gene Regulation and Its Therapeutic Potential”. The GRS (July 13-14) will provide a forum for postdocs and graduate students to present their work and discuss new ideas in the field, and it will include a career mentorship panel. The goal of the GRS is to contribute to the advancement of scientific discovery in RNA biology by creating a collegial, inclusive, and trainee-focused environment to facilitate both scientific and career development of attendees. The five-day GRC program (July 14-19) will include talks from trainees, early stage, and senior scientists in RNA biology, all of whom are at the cutting-edge of the post-transcriptional gene regulation field. In addition, the GRC will include a Power Hour that specifically addresses issues related to increasing participation and retention of broad and diverse talent in STEM fields. Attendance at the GRC and GRS will be capped at 200 and 70 attendees, respectively. This small conference size will help to ensure that there is ample opportunity for open discussion and meaningful interactions among the participants that propel new insights into post-transcriptional gene regulation. All organisms respond to their environment and maintain normal cell behavior through post-transcriptional gene regulation. By regulating gene expression post-transcriptionally through RNA splicing, 3´ end formation, RNA stability, etc., cells establish the proper gene expression patterns required for any given environment. Thus, an understanding of these mechanisms in RNA biology is essential to define both normal and disease states and will be important in developing therapies. For example, the recent history of COVID19 mRNA vaccine development exemplifies how the fundamental RNA biology that drives posttranscriptional gene regulation can broadly impact the human condition. An in-depth understanding of posttranscriptional gene regulation was required for the development of mRNA vaccines. The scientific programs at the Post-Transcriptional Gene Regulation GRC and GRS address cutting-edge topics in the field, including RNA modifications and structure, RNA and disease, and noncoding RNA, among others. Importantly, the science that will be presented at the GRC/GRS is expected to be unpublished work, so that the conferences stimulate discussions on novel ideas and emerging questions, and thus catalyze scientific advances in the field.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项将为2024年戈登研究会议（GRC）提供有关题为“生命世界中RNA的多功能性”以及其相关的戈登研究研讨会（GRS），“基因调节中的RNA及其治疗潜力的RNA”的转录后基因监管的支持。 GRS（7月13日至14日）将为博士后和研究生提供一个论坛，以介绍他们的作品和讨论该领域的新想法，其中包括职业心态小组。 GRS的目的是通过创建一个大学，包容和以培训的为重点的环境来促进参与者的科学和职业发展，从而为RNA生物学的科学发现发展做出贡献。为期五天的GRC计划（7月14日至19日）将包括学员，早期和RNA生物学高级科学家的会谈，所有这些人都处于转录后基因调节领域的尖端。此外，GRC将包括一个电动时刻，该小时专门解决了与增加参与和保留STEM领域的广泛和多样性有关的问题。参加GRC和GRS的出席人数分别为200和70名与会者。这个小的会议规模将有助于确保有足够的机会进行公开讨论和有意义的互动，从而将新见解推向转录后基因调节。所有生物都会通过转录后基因调节来应对其环境，并维持正常的细胞行为。通过在转录后通过RNA剪接，3最终形成，RNA稳定性等控制基因表达，细胞建立了任何给定环境所需的适当基因表达模式。这是对RNA生物学中这些机制的理解对于定义正常状态和疾病状态至关重要，并且对于开发疗法至关重要。例如，COVID19的最新历史mRNA疫苗发育体现了驱动转录后基因调控的基本RNA生物学如何广泛影响人类状况。需要深入了解mRNA疫苗的开发后对转录后基因调节。转录后基因调控GRC和GRS的科学程序涉及该领域的尖端主题，包括RNA修饰和结构，RNA和疾病，以及非编码RNA等。重要的是，预计将在GRC/GRS上介绍的科学将是未发表的作品，因此会议激发了对新思想和新兴问题的讨论，从而促进了该领域的科学进步。该奖项反映了NSF的法定任务，并认为通过基金会的知识优点和广泛的影响，通过评估获得了评估，以评估来获得珍贵的支持。