Mendelian Randomization analysis of 5p15.33, telomere length and lung cancer risk: results from 14,324 cases and 10,783 controls in the Transdisciplinary Research in Cancer of the Lung (TRICL) group of the International Lung Cancer Consortium (ILCCO)

5p15.33、端粒长度和肺癌风险的孟德尔随机分析：来自国际肺癌联盟 (ILCCO) 肺癌跨学科研究 (TRICL) 小组的 14,324 例病例和 10,783 例对照的结果

• 批准号: 345576
• 负责人: Kachuri Mirlinda
• 金额: $ 0.22万
• 依托单位: Lunenfeld-Tanenbaum Research Institute (Toronto)
• 依托单位国家: 加拿大
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-01-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=345576&lang=en
• 关键词: Lung Cancer; Mendelian Randomization; Telomere Length; Telomeres

Telomeres are structures that cap the ends of chromosomes and play an important role in maintaining genome stability. In normal human cells, telomeres shorten with each round of cell division until they reach a critical length, which triggers cell death.

端粒是限制染色体末端并在维持基因组稳定性中起重要作用的结构。在正常的人类细胞中，端粒缩短了每一轮细胞分裂，直到达到临界长度，从而触发细胞死亡。