Structure, dynamics and causality in protein interaction networks

蛋白质相互作用网络的结构、动力学和因果关系

• 批准号: RGPIN-2015-05707
• 负责人: Michnick, Stephen
• 金额: $ 3.79万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=590589
• 关键词: Structure; dynamics; causality; protein; interaction

Problem and Hypothesis: The importance of protein-protein interactions (PPIs) to biology is reflected in the enormous efforts to study them on a large scale, including our own efforts, which resulted in a first description of a PPI network in vivo (Tarassov, et al. Science, 2008). In the past funding period we have developed and validated a novel approach to study dynamics of biochemical networks and to determine protein functions, discovery of pathways and a novel mechanism of allostery. The method is based on measuring dynamics of homomeric protein complexes (HPC) on a large scale.

问题和假设：蛋白质-蛋白质相互作用（PPI）对生物学的重要性反映在大规模研究它们的巨大努力中，包括我们自己的努力，这导致了体内 PPI 网络的首次描述（Tarassov，等人，2008）。在过去的资助期间，我们开发并验证了一种新方法来研究生化网络动力学并确定蛋白质功能、发现途径和新的变构机制。该方法基于大规模测量同聚蛋白复合物 (HPC) 的动态。