Mechanisms of human skeletal muscle remodelling with exercise

运动重塑人体骨骼肌的机制

• 批准号: RGPIN-2015-04251
• 负责人: Moore, Daniel
• 金额: $ 2.11万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=589684
• 关键词: Mechanisms; human; skeletal; muscle; remodelling

Skeletal muscle is an incredibly plastic tissue resulting from its remarkable ability to break down old and/or damaged proteins and make (synthesize) new functional ones. These processes occur simultaneously and continuously, are enhanced in response to exercise and nutrition, and ultimately function to ‘remodel’ this important tissue. The synthesis of new muscle proteins (MPS) significantly determines whether a muscle gets bigger and stronger, such as with resistance exercise (REX) through the synthesis of force-generating myofibrillar (MYO) proteins, and/or develop a greater endurance capacity, such as with endurance exercise (END) through the synthesis of energy-producing mitochondrial (MITO) proteins.

骨骼肌肉是一个令人难以置信的塑料组织，从其出色的蛋白质分解蛋白质，并使E）同时且连续地出现新功能。 （MPS）显着确定是否通过综合力生成肌原纤维（MyO）蛋白质和/或或或或或或或或或或或或或或或或或或或或或或或或或或或在内，是否会通过合成（结束）来发展更大产生能量的线粒体（mito）蛋白。