Development of a pseudo-incoherent homogeneous light source using a laser-coupled multimode fiber optic for biomedical applications

使用激光耦合多模光纤开发用于生物医学应用的伪非相干均匀光源

• 批准号: 486057-2015
• 负责人: Ung, Bora
• 金额: $ 1.82万
• 依托单位: École de technologie supérieure
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=585367
• 关键词: Development; pseudo; incoherent; homogeneous; light

Flow cytometry is a critical technology with a host of applications in bioengineering, basic research, and most notably, in clinical care for the rapid and accurate diagnosis of several illnesses including some cancers. A conventional cytometer is a bulky, expensive and highly-specialized piece of scientific equipment. Recent technological advances in photonics have paved the way for the democratization of the cytometer by means of a compact, portable, robust, easy-to-use and cost-effective fiber-optic flow cytometer. A fundamental challenge that limits the accuracy of current fiber-optic based cytometers pertains to the quality of the illumination source required for the interrogation zone. The goal of this project is to develop a multimode optical fiber (MMF) specially designed for coupling with a laser diode in such a way that the fiber output illumination beam is as homogeneous as possible. To attain this goal, the problem is tackled on two fronts: (1) the design, fabrication and characterization of the MMF itself, and (2) the optimization of the diode laser source parameters. It is expected that this project will help foster innovation in fiber-optic illumination schemes and spur advances in a promising technological platform (i.e. the fiber-optic flow cytometer) that benefits the health of Canadians and the Canadian based biomedical industry.

流式细胞术是一项关键技术，在生物工程、基础研究和大多数领域都有广泛的应用。 值得注意的是，在临床护理中，可以快速准确地诊断包括某些癌症在内的多种疾病。一个 传统的细胞仪是一种体积庞大、昂贵且高度专业化的科学设备。最近的 光子学技术的进步为细胞仪的民主化铺平了道路 紧凑、便携、坚固、易于使用且经济高效的光纤流式细胞仪。根本性的挑战 限制当前光纤细胞仪精度的因素与照明源的质量有关 审讯区所需。该项目的目标是开发多模光纤（MMF） 专为与激光二极管耦合而设计，光纤输出照明光束如下 尽可能同质。为了实现这一目标，需要从两个方面解决问题：（1）设计、制造 以及MMF本身的表征，以及（2）二极管激光源参数的优化。这是 预计该项目将有助于促进光纤照明方案的创新，并推动光纤照明方案的进步 有前途的技术平台（即光纤流式细胞仪）有利于加拿大人和 加拿大的生物医学产业。