Low Coordinate Main Group Chemistry: Discovery and Innovation

低配位主族化学：发现与创新

• 批准号: 37397-2012
• 负责人: Baines, Kim
• 金额: $ 5.1万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=568798
• 关键词: Low; Coordinate; Main; Group; Chemistry

Beginning with the synthesis of stable, unsaturated derivatives of the heavier group 13 to 15 elements in the late 1970s to early 1980s, an impressive number of compounds once thought to be "non-existent" have now been synthesized, a true testament to the determination and skill of the global main group synthetic chemistry community. The driving force behind this area of research was often the innate curiosity of academic chemists who were inspired by the challenging syntheses and who desired to understand the bonding in these important, fundamental species. Furthermore, such molecules were, most often, the best and only starting materials for the construction of novel molecular targets. The recent discoveries of a stable distannyne (triply bonded tin derivative) which undergoes a reversible addition reaction (a key step in catalytic transformations), of stable silyl cations which are vital players in the catalytic degradation of environmental pollutants such as organofluorides and polyethers and of germanium cations which are envisioned as unique catalysts for the asymmetric synthesis of advanced pharmaceutical intermediates have dramatically shifted the perception of the value of this area of chemistry. Unsaturated main group compounds now offer an unexplored avenue of inquiry in the global search for innovative solutions for the major challenges facing today's world. The future for these compounds has never been brighter. Over the next granting period, we will explore the synthesis and the mechanistic chemistry of unsaturated main group compounds with the goal of providing to the scientific community a detailed understanding of the reactivity of these compounds, something that is critically needed if the potential of this class of molecules is to be realized.

从1970年代末至1980年代初的稳定，不饱和衍生物的合成开始，现在已经合成了曾经被认为是“不存在的“不存在”的令人印象深刻的化合物，这是整合的真实证明，这是全球主要小组合成化学社区的确定和技能的真实证明。这一研究领域背后的推动力通常是学术化学家的先天好奇心，这些化学家受到了充满挑战的合成的启发，并希望了解这些重要的，基本的物种中的纽带。此外，这种分子通常是用于构建新分子靶标的最好和唯一的起始材料。最近发现稳定的分散剂（三重键锡衍生物）的发现，该发现经历了可逆的添加反应（催化转化的关键步骤），稳定的甲硅烷基阳离子是催化环境污染物的至关重要的参与者，例如有机氟化物和多维特型的令人羡慕的效率，是令人羡慕的效率，这些都是令人羡慕的效率，这些效率是令人羡慕的效率。中间人极大地改变了对该化学区域的价值的看法。现在，不饱和的主要团体化合物在全球搜索当今世界面临的主要挑战的全球搜索方面提供了未开发的查询途径。这些化合物的未来从未如此明亮。在下一个批准期间，我们将探讨不饱和主要群体化合物的合成和机械化学，目的是为科学界提供对这些化合物的反应性的详细理解，如果要实现这类分子的潜力，这是非常需要的。