Computational Guidance for Rapid Evaporative Ionization Mass Spectrometry

快速蒸发电离质谱的计算指导

• 批准号: 474560-2015
• 负责人: Fichtinger, Gabor
• 金额: $ 10.89万
• 依托单位: Queen's University
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments - Category 1 (<$150,000)
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=565004
• 关键词: Computational; Guidance; Rapid; Evaporative; Ionization

Rapid evaporative ionization mass spectrometry (REIMS) is a revolutionary technique that allows real-time characterization of human tissue and bacterial species by analysis of aerosol released during electrosurgical dissection or evaporated and ionized. This revolutionary technique still has a shortcoming in that it lacks spatial awareness. We propose to provide computational guidance for REIMS by integrating it into a computer-assisted surgery research platform currently available at Queen's University. The resulting research platform will allow surgeons to record and render real-time pathological and bacteriological information in the 3D space, relative to a patient's anatomy, superimposed on pre-operative and intra-operative imagery. The resulting new research platform is expected to ignite transformative changes across the full spectrum of computer-assisted surgery, accelerating progress and increasing our productivity in terms of translation of scientific and engineering results to practical use.

快速蒸发电离质谱法（REIMS）是一种革命性的技术，可以通过分析在电外科解剖过程中释放或蒸发和离子化的气溶胶对人体组织和细菌物种进行实时表征。这种革命性的技术仍然存在缺点，因为它缺乏空间意识。我们建议通过将REIM集成到皇后大学目前可用的计算机辅助手术研究平台中，为REIM提供计算指南。由此产生的研究平台将使外科医生能够在3D空间中记录并渲染实时的病理和细菌学信息，相对于患者的解剖结构，叠加在术前和术中术中图像上。预计由此产生的新研究平台将在整个计算机辅助手术中激发变革性变化，加速进步并提高我们的生产力，从而将科学和工程结果的翻译成果提高到实际使用。