Robotic breast cancer surgery

机器人乳腺癌手术

• 批准号: 549590-2020
• 负责人: Fichtinger, Gabor
• 金额: $ 17.31万
• 依托单位: Queen's University
• 依托单位国家: 加拿大
• 项目类别: Collaborative Health Research Projects
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=699976
• 关键词: Robotic; breast; cancer; surgery

Breast cancer affects 1 in 8 women during their lives and is the second-leading cause of female cancer related deaths. The ideal treatment is breast-conservation surgery during its early stage to remove the cancer while conserving healthy parts of the breast. Wirth current resection methods, on average, one out of every three women undergoing breastconservation surgery needs at least one additional surgery due incomplete tumor resection. Repeat surgery leads to increased risk of postoperative complications, impaired cosmetics, delayed radiation therapy, increased psychological distress, and increased costs and risks of undergoing a second general anesthesia. Repeat surgery often leads to full mastectomy, which is a traumatic experience for a patient who expected a curative treatment with breastconservation. As early stage breast cancer is not palpable or visible, surgeons tend to apply generous safety margins around the target tumor and remove a great deal of healthy breast tissue. In current practice, up to 40% of patients who undergo breast-conservation surgery experience severe breast deformity that requires surgical reconstruction, but over half of these women do not get treated due to lack reconstructive surgical capacity. In this research, we aim to develop NaviKnife, a next-generation breast conserving surgery navigation system to achieve complete tumor resection with minimal tissue loss. NaviKnife builds on novel multiparametric ultrasound imaging to accurately target the cancer prior to resection and novel real-time metabolomic tissue typing to identify and trace the tumor boundary during resection while guided by a simple robotic arm. NaviKnife assists the surgeon in precise tumor resection and allows for systematic probing of the resection cavity for residual cancer and, if necessary, guides the surgeon in targeted shaving of the cavity wall with minimal loss of healthy tissue, thus guaranteeing complete tumor removal before the wound is closed.

乳腺癌影响八分之一的女性一生，是导致乳腺癌的第二大原因 女性癌症相关死亡。理想的治疗方法是在保乳期进行保乳手术。 早期切除癌症，同时保留乳房的健康部分。通电电流 平均有三分之一的女性接受保乳术 由于肿瘤切除不完全，手术需要至少进行一次额外手术。 重复手术会导致术后并发症、化妆品受损、 延迟放射治疗、增加心理困扰以及增加费用和风险 进行第二次全身麻醉。重复手术通常会导致全乳房切除术， 对于希望通过保乳进行治愈性治疗的患者来说，这是一次痛苦的经历。 由于早期乳腺癌无法触及或可见，外科医生倾向于应用 目标肿瘤周围足够的安全裕度并切除大量健康乳房 组织。在目前的实践中，高达 40% 的患者接受了保乳手术 经历严重的乳房畸形，需要手术重建，但超过一半 这些妇女由于缺乏重建手术能力而没有得到治疗。 在这项研究中，我们的目标是开发 NaviKnife，一种下一代保乳手术 导航系统实现肿瘤的完全切除，组织损失最小。导航刀 以新颖的多参数超声成像为基础，可在治疗前准确定位癌症 切除和新颖的实时代谢组学组织分型来识别和追踪肿瘤 在简单的机械臂引导下进行切除过程中的边界。 NaviKnife 协助 外科医生进行精确的肿瘤切除，并允许系统地探测切除腔 针对残余癌症，如有必要，指导外科医生有针对性地剃除腔壁 健康组织的损失最小，从而保证在手术前完全切除肿瘤 伤口已闭合。