Evolutionary biology of deleterious mutations and sex

有害突变和性别的进化生物学

• 批准号: 288256-2010
• 负责人: Agrawal, Aneil
• 金额: $ 2.91万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=548161
• 关键词: Evolutionary; biology; deleterious; mutations; sex

The ubiquity of sex and recombination across disparate forms of biological life indicate that the selective pressures favouring genetic exchange are powerful and widespread. Understanding this source of selection is not only important to basic science but may allow for improved management of biological resources (i.e., agriculture, fisheries, forestry, conservation). However, the ultimate reasons for sex and recombination have been elusive. Although there has been considerable progress in understanding the conceptual issues underlying this classic problem, many theoretical and empirical questions remain. The proposed research outlines several projects designed to illuminate the importance of different factors affecting the evolution of sex. Specifically, theory will be developed to evaluate how different sources of genetic variation (e.g., deleterious mutation, spatial heterogeneity in selection, host-parasite coevolution) contribute to selection for sex. Empirically, we will test how sex and recombination affect the mean and variance in fitness under different experimental conditions.

跨不同形式的生物学生命的性别和重组的无处不在表明，有利于遗传交换的选择性压力是强大而广泛的。了解这种选择来源不仅对基础科学很重要，而且可以改善生物资源的管理（即农业，渔业，林业，保护）。 但是，性和重组的最终原因是难以捉摸的。 尽管在理解这个经典问题的概念问题方面取得了很大进展，但仍然存在许多理论和经验问题。 拟议的研究概述了几个旨在阐明影响性别进化的因素的重要性的项目。 具体而言，将开发理论来评估不同的遗传变异来源（例如，有害突变，选择中的空间异质性，宿主 - 寄生虫协同进化）如何有助于选择性别。 从经验上讲，我们将测试性别和重组如何影响不同实验条件下适合度的平均值和方差。