A genome-wide analysis of parasitic fitness in the Dutch elm disease fungus Ophiostoma novo-ulmi

荷兰榆树病真菌 Ophiostoma novo-ulmi 寄生适应性的全基因组分析

• 批准号: 105519-2013
• 负责人: Bernier, Louis
• 金额: $ 2.91万
• 依托单位: Université Laval
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=545165
• 关键词: genome; wide; analysis; parasitic; fitness

More than one billion elms have been killed by two successive pandemics of Dutch elm disease (DED) since the early 20th century. The highly aggressive fungus Ophiostoma novo-ulmi is responsible for the current DED pandemic and has had a dramatic impact on populations of Ulmus americana, the most widespread native elm species in North America. Understanding the genetic basis of the host-pathogen interaction leading to DED is basic to developing control methods involving manipulation of the pathogen or its host. The general objective of the proposed research is to identify, characterize and manipulate genes that contribute to overall parasitic fitness in O. novo-ulmi. More specifically, we are targeting genes involved in pathogenicity, as well as genes that control the transition between the two growth forms (yeast and mycelium) observed in the DED fungi when they develop in their host.

自20世纪初期以来，两种连续的荷兰榆树疾病（DED）的大流行者杀死了超过十亿的榆树。高度侵略性的真菌Novo-Ulmi负责当前的DED大流行，并对北美最广泛的本地榆树物种Ulmus Americana的种群产生了巨大影响。了解导致DED的宿主 - 病原体相互作用的遗传基础是开发涉及病原体或其宿主操纵的控制方法的基础。拟议研究的一般目标是识别，表征和操纵基因，这些基因有助于Novo-Ulmi的总体寄生状态。更具体地说，我们靶向涉及致病性的基因，以及控制两种生长形式（酵母和菌丝体）在宿主中发育时观察到的两种生长形式（酵母和菌丝体）之间的过渡。