Why certain viruses don't get along in mosquitoes. The molecular mechanism.

为什么某些病毒不能在蚊子体内相处。

• 批准号: FT230100465
• 负责人: Dr Andrii Slonchak
• 金额: $ 56.01万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-06-29 至 2028-06-28
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT230100465
• 关键词: Why; certain; viruses; don; get

The overall goal of this project is to obtain an understanding of how certain insect-only viruses make mosquitoes incapable of transmitting diseases. These viruses, called insect-specific flaviviruses, can be employed as biocontrol agents for mosquito-borne human and veterinary diseases. However as it is currently unknown how exactly they affect mosquitoes, the safety and efficacy of their use can't be predicted. The proposed project will dissect the very intricate mechanisms of interactions between insect-specific flaviviruses and mosquitoes and explain how exactly they prevent disease transmission. It should generate novel fundamental knowledge, implement innovative methodologies and provide training for students and junior scientist.

该项目的总体目标是了解某些仅昆虫病毒使蚊子无法传播疾病的理解。这些称为昆虫特异性黄素病毒的病毒可以用作蚊子传播的人类和兽医疾病的生物防治剂。然而，由于目前尚不清楚它们如何影响蚊子，因此无法预测其使用的安全性和功效。拟议的项目将剖析昆虫特异性黄病毒和蚊子之间相互作用的非常复杂的机制，并解释它们如何确切防止疾病传播。它应该产生新颖的基本知识，实施创新方法并为学生和初级科学家提供培训。