Robustness in developmental systems: how early development buffers genetic and environmental variation

发育系统的稳健性：早期发育如何缓冲遗传和环境变异

• 批准号: 238938-2013
• 负责人: Nilson, Laura
• 金额: $ 2.19万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=524508
• 关键词: Robustness; developmental; systems; how; early

It is becoming clear that there exists abundant genetic and environmental variation that the developing organism must buffer against to produce a robust phenotype. Understanding the molecular genetic mechanisms that are involved in this buffering mechanism are necessary for a complete understanding of how shape, form, and proportion are generated during development. By integrating microfluidics technology, high throughput imaging, and artificial selection, my research program uses an innovative approach to studying in vivo how gene expression variation and function is regulated to produce a robust phenotype in spite of variation in the genotype, the environment, or both. This research will provide insight into how organisms develop robustly in the realistic context of a viable organism, and will improve our understanding of the factors affecting adaptation of organisms when their natural environment is perturbed.

很明显，存在大量的遗传和环境变异，发展中有机体必须缓冲以产生强大的表型。了解这种缓冲机制所涉及的分子遗传机制对于完全了解在发育过程中如何产生形状，形式和比例是必要的。通过整合微流体技术，高吞吐量成像和人工选择，我的研究计划使用创新的方法来研究基因表达变异和功能如何调节基因型，环境或两者兼而有之产生可靠的表型。这项研究将提供有关生物体在可行生物体的现实背景下如何发展的洞察力，并将提高我们对影响生物自然环境适应自然环境的因素的理解。