Azo polymers for photo-reversible bio-surfaces

用于光可逆生物表面的偶氮聚合物

• 批准号: 227889-2009
• 负责人: Barrett, Christopher
• 金额: $ 5.46万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=524138
• 关键词: Azo; polymers; photo; reversible; bio

Cell interactions on surfaces have attracted much recent attention from many materials chemists and physicists, since powerful tools are now available to probe these delicate structures in their native environment at the smallest scales, and many questions can now be framed in chemical terms. Understanding the surface conditions that permit cells to live and function, then permits biomedical engineering advances in regenerative medicine, and tissue repair and replacement. In addition to the chemistry of molecular groups exposed on a surface to a cell, growing cells are also very sensitive to the softness of the surface material, the thickness, the water content, - or + charge, and ion concentrations and gradients. In general, the more 'biological' the artificial surface can be made to appear (wet, soft, charged, warm, and rich in ions and specific functional groups), the more biocompatible it will be with respect to cell adhesion, survival, and function. In order to control the biological interface then, one needs to be able both to measure all of these properties in situ in a true biological environment, and to have the power to manipulate and tune these properties over a wide range with simple preparation protocols.

表面上的细胞相互作用最近引起了许多材料化学家和物理学家的广泛关注，因为现在可以使用强大的工具以最小的尺度在其天然环境中探测这些微妙的结构，并且许多问题现在可以用化学术语来解释。 了解允许细胞生存和发挥功能的表面条件，然后允许再生医学以及组织修复和替换方面的生物医学工程取得进展。 除了暴露在细胞表面的分子基团的化学性质外，生长中的细胞还对表面材料的柔软度、厚度、含水量、-或+电荷以及离子浓度和梯度非常敏感。 一般来说，人造表面越“生物化”（湿润、柔软、带电、温暖、富含离子和特定官能团），其在细胞粘附、存活和生长方面的生物相容性就越高。功能。 为了控制生物界面，人们需要能够在真实的生物环境中原位测量所有这些特性，并能够通过简单的制备方案在大范围内操纵和调整这些特性。