Regulatory mechanisms of Na+ and fluid absorption across alveolar epithelium

肺泡上皮钠和液体吸收的调节机制

• 批准号: 312177-2011
• 负责人: Brochiero, Emmanuelle
• 金额: $ 2.19万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=481166
• 关键词: Regulatory; mechanisms; Na+; fluid; absorption

Effective gas exchange in the lungs requires alveolar air spaces virtually free of liquid. It has been established that liquid clearance from alveoli is mainly driven by active Na+ transport through ENaC channels, located at the apical membrane of alveolar epithelial cells. The regulatory mechanisms of ENaC as well as Na+ and fluid absorption across alveolar cells are complex and remain incompletely understood. Since 2005, our research program thus aims at better understanding the mechanisms that control alveolar Na+ and liquid absorption. During the last few years, we have made some significant progress by identifying several crucial regulatory elements of alveolar transport. Indeed, we have identified several factors including the activity of another class of ion channels, the K+ channels, controlling ENaC gene promoter activity and ENaC expression, as well as alveolar Na+ and liquid transport.

肺部有效的气体交换需要几乎没有液体的肺泡空间。已经确定，来自肺泡的液体清除率主要由位于肺泡上皮细胞的顶膜的ENAC通道的主动Na+转运驱动。 ENAC以及Na+的调节机制以及跨肺泡细胞的流体吸收是复杂的，并且仍然不完全理解。自2005年以来，我们的研究计划旨在更好地了解控制肺泡Na+和液体吸收的机制。在过去的几年中，我们通过识别肺泡转运的几个关键调节元素取得了重大进展。实际上，我们已经确定了几个因素，包括另一类离子通道的活性，K+通道，控制ENAC基因启动子活性和ENAC表达以及肺泡Na+和液体传输。