Defining the shape of evolutionary landscapes

定义进化景观的形状

• 批准号: 298397-2010
• 负责人: Blouin, Christian
• 金额: $ 1.82万
• 依托单位: Dalhousie University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=480728
• 关键词: Defining; shape; evolutionary; landscapes

It is possible to infer the past by observing the diversity of genes that exist today only if we understand the mechanics of diversification. In the case of genes and their products, we call this diversification "evolution". We further represent the natural history of genes using phylogenetic trees: where each leaf is an observation, each bifurcation an assumed ancestor to its leaves, and the root being the last common ancestor to all leaves. This proposal is about the rigorous understanding of how the most likely tree can be found, and about the meaning of trees inferred from the 3D structures of proteins.

只有了解多样化的机制，才有可能通过观察当今存在的基因多样性来推断过去。就基因及其产物而言，我们将这种多样化称为“进化”。我们使用系统发育树进一步表示基因的自然历史：其中每片叶子都是一个观察结果，每个分叉都是其叶子的假定祖先，而根是所有叶子的最后一个共同祖先。该提案旨在严格理解如何找到最有可能的树，以及从蛋白质 3D 结构推断出树的含义。