Unravelling the genetic causes of bipolar disorder: lessons from rare but highly penetrant variants in very heritable forms of illness

揭开双相情感障碍的遗传原因：从高度遗传性疾病中罕见但高度渗透的变异中汲取教训

• 批准号: nhmrc : 1063960
• 负责人: Dr Janice Fullerton
• 金额: $ 47.07万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/unravelling-genetic-causes-forms-illness/455093
• 关键词: Unravelling; genetic; causes; bipolar; disorder

Bipolar disorder is a severe mood disorder affecting over 350,000 Australians, for which the causes remain largely unknown. This project will apply a powerful new technology, exome sequencing, to rare families with highly heritable forms of bipolar disorder to identify specific genetic factors which increase disease risk. A greater understanding of the genetic causes of this illness may eventually lead to improvements in diagnosis, treatment and quality of life of people suffering with this debilitating mental illness.

双相情感障碍是一种严重的情绪障碍，影响着超过 350,000 名澳大利亚人，其原因仍然很大程度上未知。该项目将应用一种强大的新技术——外显子组测序，对患有高度遗传性双相情感障碍的罕见家庭进行鉴定，以识别增加疾病风险的特定遗传因素。更好地了解这种疾病的遗传原因可能最终会改善患有这种使人衰弱的精神疾病的人们的诊断、治疗和生活质量。