Neuregulin dependent neuronal migration and schizophrenia

神经调节蛋白依赖性神经元迁移和精神分裂症

• 批准号: nhmrc : 630452
• 负责人: Dr Janice Fullerton
• 金额: $ 19.81万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/neuregulin-dependent-neuronal-migration-schizophrenia/98855
• 关键词: Neuregulin; dependent; neuronal; migration; schizophrenia

Schizophrenia effects 1-100 Australians and is responsible for $2.2 billion in health costs, disables thought and emotion and is devastating to the individual, the family and the community. We need to develop drugs able to reverse the root cause of schizophrenia. We know that schizophrenia is caused by risk genes and environments and impacts brain maturation. We will test how one such gene, neuregulin, acts to derail the normal development of the human cerebral cortex in patients who suffer.

精神分裂症影响 1 至 100 名澳大利亚人，造成 22 亿澳元的健康费用，导致思维和情感丧失，对个人、家庭和社区造成毁灭性打击。我们需要开发能够扭转精神分裂症根本原因的药物。我们知道，精神分裂症是由风险基因和环境引起的，会影响大脑的成熟。我们将测试这样一种基因——神经调节蛋白——如何破坏患者大脑皮层的正常发育。