Understanding the mechanisms that regulate spleen organogenesis

了解调节脾脏器官发生的机制

• 批准号: nhmrc : 1078247
• 负责人: Jonathan Tan
• 金额: $ 27.62万
• 依托单位: Bond University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-mechanisms-regulate-spleen-organogenesis/518570
• 关键词: Understanding; mechanisms; regulate; spleen; organogenesis

Spleen is a organ with regenerative capacity but the cells driving this have been largely unexplored. A cell-type essential for spleen tissue formation was recently discovered, termed a spleen organiser cell. We are now are attempting to understand where these cells originate from, what cells they develop into, and which genes are important for spleen regeneration. These findings will advance fundamental knowledge of spleen development and lead to better strategies for spleen transplant therapy.

脾脏是一个具有再生能力的器官，但驱动其再生的细胞在很大程度上尚未被探索。最近发现了一种对脾组织形成至关重要的细胞类型，称为脾组织细胞。我们现在正试图了解这些细胞起源于何处，它们发育成什么细胞，以及哪些基因对脾脏再生很重要。这些发现将增进脾脏发育的基础知识，并制定更好的脾移植治疗策略。