I-Corps: Positron Emission Tomography Helmet

I-Corps：正电子发射断层扫描头盔

• 批准号: 1929529
• 负责人: Julie Brefczynski-Lewis
• 金额: $ 5万
• 依托单位: West Virginia University Research Corporation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-15 至 2022-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1929529&HistoricalAwards=false
• 关键词: Corps; Positron; Emission; Tomography; Helmet

The broader impact/commercial potential of this I-Corps project is to improve patient outcomes by bringing whole brain imaging directly to the patient for safe, fast, and better tolerated diagnostics. Compared to existing brain imaging technologies, the Positron Emission Tomography (PET) helmet brain imager overcomes limitations related to radioactive dose, portability, motion tolerance and cost. The lower dose required by the device permits screening or longitudinal monitoring of patients in various cases, such as brain injury, Alzheimer's, epilepsy, stroke rehabilitation, Parkinson's disease, addition and other neurological and mental health disorders. The portable nature allows bedside imaging directly in patient rooms, as well as onsite imaging in military and athletic settings, including immediately after head injuries. The device's motion tolerance helps address hospital inefficiency and extra cost from rescanning patients due to movement artifacts, and the discomfort of remaining still, especially for elderly and injured patients. The low cost and small footprint compared to standard PET/CT systems, results in a device with utility beyond just large medical facilities, as it can be used in smaller rural clinics, sporting/military medical facilities, and in research studies of previously difficult to study brain functions.This I-Corps Project will help bring the Positron Emission Tomography (PET) Helmet brain imager into use by clinics, sporting/ army medical centers, and research institutions. The instrument is a ring of detectors that can be placed around the head of a patient to non-invasively provide information of activity in different brain regions. This device requires only 10-25% of the typical clinical PET radiation dose due to the close proximity of the detectors to the patient's head, and published data show high efficiency and sensitivity of the detectors using industry standard testing. Moreover, the PET Helmet system can be transported to the desired location of imaging scanner, and a current research project involves testing the imager bedside for human patients with traumatic brain injury. The device moves with the head of the patient allowing for motion tolerance as well as upright imaging, and we have demonstrated appropriate task-related brain imaging during an upright walking task in human participants.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该I-Corps项目的更广泛的影响/商业潜力是通过将整个脑成像直接带给患者以获得安全，快速且耐受性更好的诊断来改善患者的预后。与现有的脑成像技术相比，正电子发射断层扫描（PET）头盔脑成像器克服了与放射性剂量，可移植性，运动耐受性和成本相关的限制。该设备所需的较低剂量允许在各种情况下对患者进行筛查或纵向监测，例如脑损伤，阿尔茨海默氏症，癫痫，中风康复，帕金森氏病，添加性和其他神经和心理健康疾病。便携式性质允许直接在病房中进行床头成像，以及在军事和运动环境中的现场成像，包括头部受伤后立即进行。该设备的运动耐受性有助于解决由于行动伪像导致的患者的医院效率低下和额外的费用，以及静止不动的不适，尤其是对于老年人和受伤的患者而言。与标准的PET/CT系统相比，低成本和较小的占地面积会导致具有超越大型医疗设施的实用性的设备，因为它可以在较小的乡村诊所，体育/军事医疗设施，体育/军事医疗设施以及以前难以研究大脑功能的研究中。这项I-CORPS项目将有助于将positrons发射术（PET）发射型（PET）脑部发射脑脑中的脑部脑中的脑电图进行医学培训，并将其用于临床/陆军的使用，并将其带入临床/陆军的使用。该仪器是一个探测器的环，可以在患者的头部周围放置，以非侵入性地提供不同大脑区域的活动信息。由于探测器靠近患者的头部，该设备仅需要典型的临床PET辐射剂量的10-25％，并且发布的数据显示了使用行业标准测试的检测器的高效率和敏感性。此外，可以将宠物头盔系统运输到成像扫描仪的所需位置，而当前的研究项目涉及对脑损伤的人类患者进行成像床旁的测试。该设备以患者的头部移动，允许运动容忍和直立成像，我们在人类参与者的一项直立步行任务中展示了适当的任务相关的大脑成像。该奖项反映了NSF的法定任务，并被认为是值得通过基金会的知识分子优点和更广泛影响的审查标准来通过评估来支持的。