Targeted inhibition of polyamine synthesis for treatment of childhood neuroblastoma

靶向抑制多胺合成治疗儿童神经母细胞瘤

• 批准号: nhmrc : 1006487
• 负责人: A/Pr David Ziegler
• 金额: $ 38.45万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeted-inhibition-polyamine-childhood-neuroblastoma/109185
• 关键词: Targeted; inhibition; polyamine; synthesis; treatment

The childhood cancer, neuroblastoma, frequently has a dismal outcome despite the use of intensive therapy. Polyamines are molecules that are essential for cell survival and these are increased in aggressive neuroblastoma. Using pre-clinical models, we have shown that inhibiting polyamine production can significantly delay neuroblastoma growth. This project aims to improve the overall efficacy of this treatment by targeting multiple steps in polyamine synthesis in combination with chemotherapy.

尽管采用强化治疗，儿童期癌症神经母细胞瘤的结果却常常令人沮丧。多胺是细胞生存所必需的分子，在侵袭性神经母细胞瘤中这些分子会增加。使用临床前模型，我们已经证明抑制多胺的产生可以显着延缓神经母细胞瘤的生长。该项目旨在通过结合化疗靶向多胺合成的多个步骤来提高这种治疗的整体疗效。