Optimising targeted polyamine depletion for treatment of childhood neuroblastoma and brain tumours

优化靶向多胺消耗以治疗儿童神经母细胞瘤和脑肿瘤

• 批准号: nhmrc : GNT1125036
• 负责人: A/Pr David Ziegler
• 金额: $ 92.82万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/optimising-targeted-polyamine-brain-tumours/1347453
• 关键词: Optimising; targeted; polyamine; depletion; treatment

Paediatric neuroblastoma and brain tumours, which often have dismal outcomes despite intensive therapy, have high levels of polyamines, which are essential for cell growth. We have shown that depleting polyamines, combined with chemotherapy, represents a highly promising therapy for neuroblastoma. We will make this exciting new treatment approach even more effective by comparing three ways of enhancing polyamine depletion, as a precursor to future neuroblastoma and brain tumour clinical trials.

小儿神经母细胞瘤和脑肿瘤尽管经过强化治疗，结果往往令人沮丧，但它们含有高水平的多胺，而多胺对细胞生长至关重要。我们已经证明，消耗多胺与化疗相结合是治疗神经母细胞瘤的一种非常有前途的疗法。我们将通过比较三种增强多胺消耗的方法，使这种令人兴奋的新治疗方法更加有效，作为未来神经母细胞瘤和脑肿瘤临床试验的先导。