A study of the plaque-modifying actions of colchicine in stable and unstable atherosclerosis: from mouse models to clinical imaging.

秋水仙碱对稳定和不稳定动脉粥样硬化斑块修饰作用的研究：从小鼠模型到临床成像。

• 批准号: nhmrc : 1127159
• 负责人: Dr Peter Psaltis
• 金额: $ 81.88万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/study-plaque-modifying-clinical-imaging/947959
• 关键词: study; plaque; modifying; actions; colchicine

Inflammation causes the plaques in arteries that cause heart attacks and strokes. There is major interest in developing drugs that reduce this inflammation for patients with heart disease. We are studying the effects of colchicine, an anti-inflammatory drug used to treat the joint disease, gout, in order to see whether it also prevents the build up of plaques and their progression to heart attacks and strokes.

炎症会导致动脉中出现斑块，从而导致心脏病发作和中风。人们对开发减轻心脏病患者炎症的药物非常感兴趣。我们正在研究秋水仙碱（一种用于治疗关节疾病、痛风的抗炎药物）的作用，以了解它是否也可以防止斑块的形成及其进展为心脏病和中风。