New approaches to target plaque inflammation in atherosclerosis

针对动脉粥样硬化斑块炎症的新方法

• 批准号: nhmrc : GNT1161506
• 负责人: Dr Peter Psaltis
• 金额: $ 38.67万
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/new-approaches-target-inflammation-atherosclerosis/1349343
• 关键词: New; approaches; target; plaque; inflammation

Atherosclerosis is the build-up of cholesterol plaques inside blood vessels that cause heart attacks. Macrophages are a type of cell that accumulate inside these plaques to make them grow. I am studying two different approaches to stop this build-up of cholesterol-rich macrophages in plaque to prevent heart attacks. One is the use of an anti-inflammatory, anti-gout drug called colchicine, and the other is to block a molecule called eukaryotic elongation factor 2 kinase (eEF2K).

动脉粥样硬化是血管内胆固醇斑块的积聚，导致心脏病发作。巨噬细胞是一种在这些斑块内积聚以使其生长的细胞。我正在研究两种不同的方法来阻止斑块中富含胆固醇的巨噬细胞的积聚，以预防心脏病发作。一种是使用一种名为秋水仙碱的抗炎、抗痛风药物，另一种是阻断一种名为真核延伸因子 2 激酶 (eEF2K) 的分子。