The structure - function relationship of NCC27, a novel nuclear chloride ion channel protein

新型核氯离子通道蛋白NCC27的结构-功能关系

• 批准号: nhmrc : 157059
• 负责人: Dr Walter Fairlie
• 金额: $ 16.11万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2001
• 资助国家: 澳大利亚
• 起止时间: 2001-01-01 至 2003-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/structure-function-relationship-channel-protein/98941
• 关键词: structure; function; relationship; NCC27; novel

Ion channels (IC) are complex proteins that regulate the transport of salts, an essential cell function. We have recently cloned a new IC, NCC27, unique in its location on the nuclear membrane, a site where they were previously thought to be unnecessary. The function of nuclear membrane ICs is unknown but our studies suggest that NCC27 is involved in regulating cell division. Because NCC27 has unique functional and structural characteristics, it will be particularly useful for answering fundamental questions relevant to the biology of animal cells: the role of nuclear membrane ICs in cell division; the way the structure of NCC27 allows it to carry out its function.

离子通道 (IC) 是调节盐转运的复杂蛋白质，盐转运是一项重要的细胞功能。我们最近克隆了一种新的 IC，NCC27，其独特的位置位于核膜上，而此前人们认为该位点是不必要的。核膜 IC 的功能尚不清楚，但我们的研究表明 NCC27 参与调节细胞分裂。由于 NCC27 具有独特的功能和结构特征，因此它对于回答与动物细胞生物学相关的基本问题特别有用：核膜 IC 在细胞分裂中的作用； NCC27 的结构允许其执行其功能的方式。