Selective targeting of apoptotic pathways for therapy

选择性靶向凋亡途径进行治疗

• 批准号: nhmrc : 1041936
• 负责人: Dr Walter Fairlie
• 金额: $ 34.55万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/selective-targeting-apoptotic-pathways-therapy/111420
• 关键词: Selective; targeting; apoptotic; pathways; therapy

The cells of all animals possess the ability to commit suicide. When this natural process of cell death is dysfunctional, diseases such as cancer arise. New anti-cancer drugs aimed at targeting key components of the cell death machinery are showing promise in some patients, but not all. Our aim is to determine whether targeting other cell death components could be a more effective approach. We will also develop new chemicals that could one day allow such strategies to be applied in the clinic.

所有动物的细胞具有自杀的能力。当这种细胞死亡的自然过程是功能失调时，会产生诸如癌症之类的疾病。旨在针对细胞死亡机械关键组成部分的新型抗癌药在某些患者中表现出希望，但不是全部。我们的目的是确定针对其他细胞死亡组件是否可能是一种更有效的方法。我们还将开发新的化学物质，有一天可以允许在诊所应用此类策略。