Structural events in insulin and IGF signalling - a nanodisc approach to a problem in cancer, diabetes and Alzheimer's disease

胰岛素和 IGF 信号传导中的结构事件 - 解决癌症、糖尿病和阿尔茨海默病问题的纳米圆盘方法

• 批准号: nhmrc : GNT1099595
• 负责人: A/Pr Hans Elmlund
• 金额: $ 75.24万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/structural-events-insulin-alzheimers-disease/1346071
• 关键词: Structural; events; insulin; IGF; signalling

Insulin and its insulin-like growth factors play a major role in three major disease states facing ageing Australians—diabetes, cancer and Alzheimer's disease. We aim to understand how these proteins send messages into cells via their so-called receptors. We will isolate the receptor molecules from cells and then image them in an advanced electron microscope to produce three-dimensional images. Our findings will have implications for the design of therapeutics targeting the above three diseases.

胰岛素和胰岛素样因素在面对澳大利亚疾病的三种主要疾病状态中起着主要作用，阿尔茨海默氏症蛋白质的目标是通过其所谓的受体将信息发送到细胞中。在环境显微镜中产生三维图像。