Roles for MAPK-ERK1-2, -catenin-TCF and Smad3 mediated signalling pathways in TGF -induced cataract

MAPK-ERK1-2、连环蛋白-TCF 和 Smad3 介导的信号通路在 TGF 诱导的白内障中的作用

• 批准号: nhmrc : 512355
• 负责人: Prof Frank Lovicu
• 金额: $ 22.61万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/roles-mapk-erk1-induced-cataract/95430
• 关键词: Roles; MAPK; ERK1; catenin; TCF

Posterior capsular opacification (PCO) is a common and costly complication of cataract surgery that is caused by aberrant growth of lens cells. The TGF growth factor family causes PCO. TGF activates three signalling pathways in the lens, MAPK-ERK1-2, -catenin-TCF and Smad3; however currently we do not know which one induces PCO. This project will identify the pathway(s) that prevent TGF from causing cataracts. This is critical for the development of pharmaceuticals to prevent PCO.

后囊膜混浊（PCO）是白内障手术中常见且昂贵的并发症，由晶状体细胞异常生长引起。 TGF 生长因子家族会导致 PCO。 TGF 激活晶状体中的三个信号通路：MAPK-ERK1-2、-catenin-TCF 和 Smad3；然而目前我们不知道哪一种因素会诱发 PCO。该项目将确定防止 TGF 引起白内障的途径。这对于开发预防 PCO 的药物至关重要。