Inductive Interactions between Lens and Optic Cup Specify Cell Fates

透镜和视杯之间的感应相互作用决定了细胞的命运

• 批准号: nhmrc : 253669
• 负责人: Prof Frank Lovicu
• 金额: $ 17.7万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-01-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/inductive-interactions-lens-cell-fates/101224
• 关键词: Inductive; Interactions; between; Lens; Optic

Normal eye development depends on interactions between embryonic eye tissues. In the front part of the eye inductive interactions between lens and optic vesicle are important for the formation and growth of lens, ciliary body and iris. Our recent studies indicate that a family of developmentally important growth factors, the Wnts, plays key roles in this process. Our proposed studies will examine, for the first time, the role of Wnts in lens, ciliary body and iris development. Specific experimental outcomes will show if Wnts are important in promoting the formation and maintenance of the front part of the lens, the lens epithelium. The outcomes will also give us information on the molecules that mediate the effects of Wnts on lens cells and if regulatory factors from the lip of the optic cup-ciliary body can influence the pathways by which Wnts can influence the lens cells. In addition we will learn if lens-derived Wnts have a role in the formation of ciliary body and iris. Identifying factors that regulate the formation of eye tissues is fundamental to understanding the molecular basis of eye disease. For example, cataract is the most common cause of blindness in the world. Cataract surgery is the most common surgical procedure and is placing an ever-increasing burden on health care budgets. Cataracts that most commonly require surgery usually involve abnormal growth and behaviour of lens cells such as occurs in posterior subcapsular cataract and posterior capsular opacification (also known as aftercataract because it occurs subsequently to cataract surgery). Identifying molecules and mechanisms that are involved in normal formation and growth of lens cells is fundamental to understanding these diseases. In addition, as it is well known that the lens is required for the normal formation of the front part of the eye, including the ciliary body and iris, results from this study may also shed light on some developmental abnormalities such as small eye.

正常的眼睛发育取决于胚胎眼组织之间的相互作用。在眼睛和视囊之间的眼睛感应相互作用的前部对于晶状体，睫状体和虹膜的形成和生长很重要。我们最近的研究表明，一个具有发展重要的增长因素（WNT）在此过程中起着关键作用。我们提出的研究将首次研究WNT在晶状体，睫状体和虹膜发育中的作用。特定的实验结果将表明Wnt是否在促进镜头上皮的前部的形成和维持中是否重要。结果还将为我们提供有关介导WNT对晶状体细胞影响的分子的信息，以及光学杯 - 丝状体唇的调节因子是否会影响WNT会影响晶状体细胞的途径。此外，我们将学习镜头衍生的Wnt是否在睫状体和虹膜的形成中起作用。识别调节眼组织形成的因素是理解眼病的分子基础的基础。例如，白内障是世界上最常见的失明原因。白内障手术是最常见的外科手术，正在为医疗保健预算带来不断增加的负担。通常需要手术的白内障通常涉及异常的生长和晶状体细胞的行为，例如在后囊下白内障和后囊囊膜不足（也称为腹腔治疗）中发生（因为它在白内障手术后发生）。识别与晶状体细胞正常形成和生长有关的分子和机制对于理解这些疾病至关重要。此外，众所周知，这项研究的正常形成眼睛的正常形成需要镜头，这项研究的结果也可能揭示出某些发育异常，例如小眼。