The role of the T cell protein tyrosine phosphatase in autoimmunity

T细胞蛋白酪氨酸磷酸酶在自身免疫中的作用

• 批准号: nhmrc : 1047055
• 负责人: Prof Tony Tiganis
• 金额: $ 43.66万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-t-cell-phosphatase-autoimmunity/111901
• 关键词: role; cell; protein; tyrosine; phosphatase

Autoimmune diseases such as type 1 diabetes, Crohns disease & rheumatoid arthritis collectively affect ~5% of Australians & are associated with the immune system attacking the body’s organs as if they were a foreign infection. Genetic studies in humans & animal studies point towards the enzyme TCPTP being important in the prevention of autoimmunity. This proposal will define the molecular & cellular pathways by which TCPTP prevents autoimmunity.

1 型糖尿病、克罗恩病和类风湿性关节炎等自身免疫性疾病共同影响了大约 5% 的澳大利亚人，这些疾病与免疫系统攻击身体器官有关，就好像它们是外来感染一样。人类和动物研究中的遗传学研究表明存在这种酶。 TCPTP 在预防自身免疫方面很重要。该提案将定义 TCPTP 预防自身免疫的分子和细胞途径。