Hepatic oxidative stress, PTPs & STAT signalling in obesity

肝脏氧化应激，PTP

• 批准号: nhmrc : 1083837
• 负责人: Prof Tony Tiganis
• 金额: $ 72.45万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/hepatic-oxidative-stress-signalling-obesity/518958
• 关键词: Hepatic; oxidative; stress; PTPs; STAT

Obesity is increasing at an alarming rate worldwide and is a leading cause of morbidity and mortality. Obesity is causally linked to the development of insulin resistance, a prelude to type 2 diabetes. In this proposal we will define a novel liver centric mechanism by which insulin resistance and oxidative stress may promote the development of morbid obesity, type 2 diabetes and liver disease.

肥胖症在全世界范围内以惊人的速度增长，是发病率和死亡率的主要原因。肥胖与胰岛素抵抗的发展存在因果关系，而胰岛素抵抗是 2 型糖尿病的前奏。在本提案中，我们将定义一种新的以肝脏为中心的机制，通过该机制，胰岛素抵抗和氧化应激可能促进病态肥胖、2 型糖尿病和肝病的发展。