Unlocking the helminth ‘early infection gap’ using 3D cell culture models

使用 3D 细胞培养模型解锁蠕虫“早期感染间隙”

• 批准号: DE240100295
• 负责人: Dr Nichola Calvani
• 金额: $ 31.58万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE240100295
• 关键词: Unlocking; helminth; early; infection; gap

This project aims to revolutionise the study of critical early host-parasite interactions using innovative 3D cell culture models, reducing our dependence on animal infections. Liver fluke is the most economically important zoonotic parasite of Australian livestock and is a significant contributor to global food insecurity. Due to the reliance of parasites on mammalian hosts to survive, very little is known about the early infection process. Expected outcomes include new knowledge on key migratory stimuli and liver fluke biology. Benefits include the identification of drug targets and vaccine candidates for use in livestock via the development of animal-free in vitro screening platforms that will serve as a prototype for other parasites.

该项目旨在利用创新的 3D 细胞培养模型彻底改变关键的早期宿主-寄生虫相互作用的研究，减少我们对动物感染的依赖。肝吸虫是澳大利亚牲畜经济上最重要的人畜共患寄生虫，也是全球粮食不安全的重要原因。由于寄生虫依赖哺乳动物宿主生存，人们对早期感染过程知之甚少。预期成果包括关于关键迁徙刺激和肝吸虫生物学的新知识。好处包括通过开发无动物体外筛选平台来确定用于牲畜的药物靶标和候选疫苗，该平台将作为其他寄生虫的原型。