Bacterial inhibition of cell signalling and apoptosis during gastrintestinal infection

胃肠道感染期间细菌抑制细胞信号传导和细胞凋亡

• 批准号: nhmrc : 1080391
• 负责人: Dr Catherine Kennedy
• 金额: $ 36.14万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/bacterial-inhibition-cell-gastrintestinal-infection/518742
• 关键词: Bacterial; inhibition; cell; signalling; apoptosis; Bacterial; inhibition; cell; signalling; apoptosis

E. coli are a major cause of severe diarrhoeal disease. In order to establish infection, E. coli inhibits a host response where cells with bacteria stuck to them are ‘killed off’ and excreted as waste. This recent discovery illuminated an unknown role for cell death in the immune response during bacterial gastroenteritis. This project will study this phenomenon further to better understand the host immune response to infection and also other gut diseases such as inflammatory bowel disease.

大肠杆菌是严重腹泻病的主要原因。为了建立感染，大肠杆菌抑制宿主反应，其中粘在细菌的细胞被“杀死”并被作为废物超过。这一最近的发现阐明了细菌胃肠炎期间的免疫响应中细胞死亡的未知作用。该项目将进一步研究这种现象，以更好地了解感染的宿主免疫响应以及其他肠道疾病，例如炎症性肠病。