Toward a deeper understanding of new DNA modifications in fear-related learning.

更深入地了解与恐惧相关的学习中新的 DNA 修饰。

• 批准号: nhmrc : GNT1160823
• 金额: $ 66.69万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/deeper-understanding-new-related-learning/1379145
• 关键词: Toward; deeper; understanding; new; DNA

The goal of this project is to test the hypothesis that a recently discovered chemical modification on DNA represents an important new mechanism for the control of gene expression underlying fear-related learning and memory. Specifically, we propose that the experience-dependent accumulation of m6dA, through direct effects on DNA structure, protein binding and epigenetic state, is necessary for activity- or learning-induced gene expression and required for fear extinction memory.

该项目的目标是检验以下假设：最近发现的 DNA 化学修饰代表了控制与恐惧相关的学习和记忆相关的基因表达的重要新机制。具体来说，我们提出，m6dA 的经验依赖性积累通过对 DNA 结构、蛋白质结合和表观遗传状态的直接影响，对于活动或学习诱导的基因表达是必要的，也是恐惧消退记忆所必需的。